It is estimated that obtaining clinical approval requires more than $1 billion in resources, and only a few compounds are approved by the U.S. Food and drug administration every year. Therefore, it is very important to obtain the maximum amount of information about biological activity, toxicological characteristics, biochemical mechanism and off-target interaction of drug candidate precursors in the earliest stage of drug discovery.
Because of its unique advantages in predictability, automation, multiplexing and miniaturization, cell-based analysis seems to be the most attractive tool to meet the high requirements in the early stage of drug discovery process. However, traditional cell screening still faces various challenges due to its limitations. Cell patterning can overcome the shortcomings of traditional cell analysis, accurately summarize human diseases or capture the side effects of drugs, and is expected to provide better accuracy in drug discovery.
Through cell patterning technology, we can realize the co-culture of multiple cells, accurately simulate the interaction between cell-cell and extracellular matrix, and accurately simulate some characteristics of solid tumors, such as their spatial structure, physiological response, secretion of soluble media, gene expression model and drug resistance mechanism. In addition, customized microfluidic cell patterning can also form an array of cancer cells and tumor spheroids to screen anticancer drugs with different concentration gradients and combinations, find the most effective drugs and the most ideal dose for you, and improve the preclinical prediction of cancer treatment.
Through cell patterning technology, we can accurately simulate the extracellular environment and flexibly adjust the drug concentration. The microfluidic cell patterned device developed by us can implement the potential concentration and combination of a variety of reagents, accurately manipulate drugs of different concentrations into the cell chamber to screen a variety of different cell drug reactions, so as to test the activity of drugs of different concentrations. This method is suitable for high-content screening and high-throughput screening, and helps you find the best drug combination as soon as possible.
The in vitro liver model established by cell patterning can maintain high cell viability and metabolic capacity, and maintain the long-term stability of hepatocyte function. Even if it is repeatedly administered, it can maintain the sensitivity of drug-induced liver injury prediction without losing specificity. These good characteristics can provide more reliable data for the potential risk of drugs and faithfully predict the response to poisons in the body. In addition, the multiple test endpoints we provide allow you to comprehensively evaluate the hepatotoxicity of drugs and provide detailed information on the potential mechanism of drug-induced liver injury.
Our cell patterning technology can accurately control the interaction between cells, maintain the physiological and pathophysiological characteristics of cardiomyocytes, promote the maturation of cardiomyocytes to mature heart tissue, and establish a functional heart model that can remain stable for several weeks. The model can reproduce the electrical activity of cardiomyocytes, show more physiological correlation than the traditional model, and is sensitive to the cytotoxicity that will damage cardiomyocytes. It can accurately predict human cardiotoxicity and provide the potential mechanism of cell injury.
Using cell patterning technology, we can control the cell microenvironment to replicate the complex renal structure, simulate the physiological environment and summarize the behavior of drugs in the kidney, including filtration, absorption and excretion. We are committed to building a functional in vitro kidney model for you, which can maintain the long-term stability of renal cell function. Even if repeated administration, it can maintain the sensitivity of drug-induced renal injury prediction without losing specificity. We aim to effectively improve your ability to effectively and efficiently test the nephrotoxicity of new compounds in preclinical stage through cell patterning technology, and provide you with detailed information on the potential mechanism of drug-induced renal injury.
Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.