Based on Cell Patterning, Creative Bioarray customizes the most appropriate 3D cancer model for you (the model is composed of tumor cells and other cells, which can better simulate the heterogeneous tumor microenvironment and its natural connective tissue formation in vivo), so as to accurately test the anticancer activity of your drugs in preclinical research and reduce the cost and time of bringing new candidate drugs to the market.
For decades, classical cancer research has focused on understanding the biological characteristics of tumor cells in vitro. However, due to the limited understanding of the impact of microenvironment on tumor cells, the extension of these findings to the in vivo environment is hindered. At present, most cell-based cancer research is carried out on cultured cells proliferating in a 2D manner. However, cells cultured under these non-physiological conditions do not represent cells existing in the complex microenvironment of tissues. This difference is considered to be an important reason for the high failure rate of anticancer drug discovery.
The in vitro 3D cancer model established by Creative Bioarray through cell patterning technology can go beyond these limitations. We can accurately control each tumor microenvironment element by integrating human cells, including patient derived cells, and conducting a series of experimental designs, so as to accurately test the anticancer activity of your drug in preclinical research.
Compared with 2D cell culture model, our in vitro 3D cancer model based on cell patterning technology can co-culture a variety of cells and form heterogeneous spheres, so as to more accurately simulate the structure and function of tissues in vivo and simulate the interaction between cell-cell and extracellular matrix. The co-culture of tumor cells with fibroblasts and endothelial cells can simulate the complex cell microenvironment in vivo. In addition, our in vitro 3D cancer model can also simulate the characteristics of angiogenesis, invasion and metastasis.
In conclusion, our in vitro 3D cancer models can accurately simulate some characteristics of solid tumors, such as their spatial structure, physiological response, secretion of soluble mediators, gene expression pattern and drug resistance mechanism. Therefore, cancer drug discovery based on in vitro 3D cancer models can open a new door for preclinical screening of new anticancer drugs and greatly accelerate the development process of anticancer drugs.
Fig.1 The applications of 3D sphere in anti-cancer treatment screening. (Costa EC, et al.,2016)
We have made great efforts to help customers develop new anticancer drugs, and we have extensive and in-depth research in the fields of colon cancer, lung cancer, breast cancer, pancreatic cancer, liver cancer, ovarian cancer and many other cancers. We can customize the most appropriate 3D cancer model according to your needs (the model is composed of tumor cells and other cells, which can better simulate the heterogeneous tumor microenvironment and its natural connective tissue formation in vivo), so as to accurately test the anti-cancer activity of your drugs in preclinical research. We provide an opportunity for highly predictable preclinical anticancer drug screening to help you reduce the cost and time to market of new drug candidates.
Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.