Creative Bioarray's cell patterning technology is a more accessible and cost-effective drug screening method. Compared with traditional drug screening methods, the system based on microfluidic cell patterning provides an ideal controlled environment for cell culture and drug testing, and has superior advantages in sample consumption, reaction time and operation cost.
At present, traditional cell culture can't simulate the natural physiological environment and cell response in vivo. On the other hand, due to the biological differences between humans and animals, animal models can't well detect the side effects of drugs. By manipulating the tumor microenvironment, our cell patterning technology can establish physiologically related in vitro tumor models and improve the preclinical prediction of cancer treatment.
Our microfluidic cell patterning technology can better simulate the different characteristics of vascular growth and tumor progression, including cell proliferation, angiogenesis, cell migration and tumor cell infiltration. Our microfluidic technology allows fine control of fluid flow and mixing through micron channels, so as to accurately control the production process of drug delivery carriers. In addition, the customized microfluidic cell patterning can also form an array of cancer cells and tumor spheroids to screen anticancer drugs with different concentration gradients and combinations, test the efficacy of the existing course of treatment, and find out the most effective drugs and the most ideal dose.
Neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and multiple sclerosis are among the highest incidence rate diseases in the world, which represent a serious public health and economic problem. The establishment of an in vitro bionic platform that can accurately replicate the functional and structural characteristics of the central nervous system and monitor its integrity changes can enhance the understanding of neurodegenerative diseases and accelerate the research and development of innovative therapies. However, traditional 2D or 3D systems cannot simulate tissue and organ functions at the in vivo level.
By providing a highly controlled cellular microenvironment, our cell patterning technology can establish in vitro neural models and evaluate the response of blood-brain barrier to physiological and pathological stimuli, including the analysis of metabolic, genetic and biochemical activities. In addition, the technology also allows the evaluation of neuronal excitability and derived synaptic activity in a controlled microenvironment, which will facilitate the characterization of compounds affecting the function of the central nervous system and the neuropharmacological analysis of active compounds of the central nervous system. In addition, the technology can screen the direct effects of multiple compounds on cells at the same time, and investigate how these drugs affect the communication between synaptic junction cultures.
The determination of cardiovascular drug action under static 2D conditions can't well reflect the complete physiological environment of vascular system in vivo. At the same time, due to ethical and economic considerations, it is not feasible to conduct high-throughput research in mammals.
The greatest advantage of using biopatterning as a platform for evaluating the effects of cardiovascular drugs is that it can finely regulate fluid flow conditions, including flow velocity, shear stress and pulsatile flow. At the same time, our microfluidic cell patterning technology allows modification of vessel geometry (bifurcation, stenosis, complex network), vessel wall surface type, and patterning of cells in 3D tissue like structures. Through cell patterning, we can generate lumen wall and heart models of lining cells, which can be used to simulate ventricular cardiomyocyte physiology, measure cardiomyocyte contractility and action potential propagation, and test targeted drugs or chronotropic drugs.
Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.