Single-cell Patterning

Creative Bioarray is equipped with the most advanced facilities and experienced staff. Based on the Cell Patterning, we provide you with single-cell patterning service, which can help you overcome the defects of traditional culture, realize single-cell culture and even single-cell analysis, so as to speed up your biological research process.

Importance of Single-cell Culture and Analysis

Single-cell culture and analysis technology is very important for understanding the behavior of single cell, accurately identifying cells and their unique sensitivity, and clarifying cell diversity and heterogeneity. For example, single-cell analysis can functionally distinguish normal cells from cancer cells and cancer cells at different stages of development; Single-cell analysis can also target specific populations to clarify the signal pathways and networks of stem cell self-renewal and differentiation.

Single-cell analysis reveals heterogeneityFig.1 Single-cell analysis reveals heterogeneity (Fang Y, et al.,2017)

Why Single-cell Patterning?

In order to realize single-cell analysis, it is very important to select and operate single cells effectively. The traditional culture tools are mostly dishes and plates. From the perspective of research and development, there are many disadvantages in using traditional culture tools for single-cell culture. For example, the traditional culture system is very uneven in both the surface properties of matrix materials and the contact with cells, and the movement of cells will also affect the experimental observation of single cell behavior.

Single-cell patterning technology can provide an evenly arranged environment to culture cells to overcome these disadvantages and allow easy comparison of data between cells without confusing other factors. In addition, single-cell patterning also allows more in-depth study of the basic characteristics of cells, so it becomes an ideal tool to study the comprehensive heterogeneity from cell behavior to molecular expression.

Applications of Single-cell Patterning

Creative Bioarray's Single-cell patterning technology allows more in-depth research on the basic characteristics of cells. It has become an ideal tool to study the comprehensive heterogeneity from cell behavior to molecular expression. At the same time, cell patterning technology makes high-throughput detection possible. At present, single-cell patterning technology has been widely used in cell biology, allowing our customers to conduct more in-depth research on cell membrane function, cell particle interaction, drugs and external stimuli at single-cell resolution. This technology supports single-cell basic and applied biological research in vitro, such as understanding of basic cell function, formation of neuronal network Drug screening, etc. At present, its main applications are:

  • Study the basic functions of cells
  • Neural network formation
  • Drug screening

What Can We Do?

Creative Bioarray's single-cell patterning method is soft lithography, which is a mature single-cell patterning method. Through this method, we can not only help you locate cells at specific locations, but also control cell morphology for more in-depth cell behavior research, such as the guidance of synapses and dendrites of divine meridians. This technology is highly accurate, effective, fast and stable. It can be used to pattern various planar and non-planar substrates to provide you with large-scale cell microarrays. The services we can provide are mainly divided into the following types:

  • Single-cell culture
  • Single-cell apoptosis analysis
  • Single-cell proteomics
  • Single-cell transcriptomics
  • Single-cell genomics
  • Single-cell migration analysis
  • Single-cell RNA sequencing 
  • Protein expression and phosphorylation at single cell level

Why Choose Us?

  • Scientific and reasonable scheme design
  • Rich experience in cell patterning projects
  • High quality and fast service
  • Professional and strong team
  • Strict quality control management

Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact ouremployees directly to ask questions if you are interested in our services, please contact us for more details.


  1. Fang Y.; et al. Studying hematopoiesis using single-cell technologies. Journal of Hematology & Oncology. 2017;10(1):27.
For research use only, not intended for any clinical use.
  • (USA)