Patterned Co-cultures

Creative Bioarray provides you with patterned co-cultures service based on Cell Patterning. Our service can help you overcome the defects of traditional culture and realize cell co-cultures. It has become a powerful tool for you to manufacture tissue engineering constructs and study cell-cell interaction in vitro. In addition, Creative Bioarray can also provide follow-up analysis services based on co-culture cell models, which can save you a lot of time and speed up the research process.

Why Patterned Co-cultures?

Co-culture is a common technology to realize the contact and interaction between cells to simulate the complex biological environment in vivo. For example, co-cultures of embryonic stem cells with inactivated fibroblasts can maintain their totipotency. However, the traditional culture dish can't well control the location, density and growth environment of cells. These difficulties can be overcome by patterned co-cultures technology. Because this technology can control the degree of homotypic and heterotypic cell-cell contact, improve the control of cell spatial distribution in culture, Therefore, patterned co-cultures support the manufacture of tissue engineering structures and the study of intercellular interactions in vitro.

Human embryonic stem cells and murine embryonic fibroblasts co-cultures at various time intervalsFig.1 Human embryonic stem cells and murine embryonic fibroblasts co-cultures at various time intervals (Khademhosseini A,et al.,2016)

Applications of Patterned Co-cultures

Creative Bioarray's patterned co-cultures technology has been widely used to enhance the control of the spatial localization of multiple cell types relative to each other, and can carry out detailed mechanical research on the process of regulating cell-cell interaction. At present, its main applications are:

  • Engineering biology
  • Synthetic biology
  • Drug screening

What Can We Do?

Creative Bioarray's patterned co-culture methods mainly include lithography, soft lithography and dielectrophoresis. Through these comprehensive technologies, we can accurately control the positioning of cells in model chemical culture, and our methods support patterned co-culture of many cell types, such as nerve cells and endothelial cells, cancer cells and vascular endothelial cells Hepatocytes and fibroblasts, embryonic stem cells and fibroblasts, etc. Our methods can help you better simulate the organization and complexity of tissue structure in vivo, develop bionic structure of tissue engineering, provide more representative tissue models than animal models, and even screen your drugs based on these models. Our comprehensive and professional services can greatly accelerate the process of your biological research, drug screening and tissue engineering research. We mainly provide the following services:

  • Support patterned co-culture of many cell types
  • Study intercellular signal transduction and communication pathways
  • Study tumor angiogenesis
  • Study the migration process of endothelial cells
  • Screening drugs by co-culture cell models in vitro

Why Choose Us?

  • Comprehensive co-culture patterning methods
  • Scientific and reasonable scheme design
  • Rich experience in cell patterning projects
  • High quality and fast service
  • Professional and strong team

Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.


  1. Khademhosseini, Ali.; et al. Co-culture of human embryonic stem cells with murine embryonic fibroblasts on microwell-patterned substrates. Biomaterials. 2016;27(36):5968-77.
For research use only, not intended for any clinical use.
  • (USA)