Creative Bioarray can help you accurately control the tumor cell microenvironment, simulate tumor angiogenesis and detect tumor migration through cell patterning technology. We aim to provide reliable technical support for the construction of bionic tumor model and further medical research, and are committed to providing you with a new technical platform for studying the interaction between tumor and microenvironment.
Vascular system plays an important role in tissue engineering and tumor biology. Tissue with vascular system is important for 3D continuous tissue culture. In addition, the growth and spread of cancer require the growth of new vascular systems for nutrient transport. Many cell types in the vascular system, such as endothelial cells, interact with cancer and regulate tumor microenvironment and cancer phenotype.
The traditional tumor sphere and scaffold methods can't incorporate the tumor vascular system interaction into the culture. Through our microfluidic cell patterning technology, capillary lumen structure can be manufactured to simulate the microvascular system in tissue. Compared with the traditional 3D tumor models, their advantage is that they can create a perfusion vascular system with accurate control through flow operation, which is very important for understanding the growth of solid tumors and the remodeling of tumor microenvironment.
Cell migration is one of the key steps in the invasion and metastasis of malignant tumors. Generally speaking, tumor cell metastasis is related to tumor location, external stimulation, tumor growth microenvironment and so on. Some studies have shown that the interface geometry of tumor tissue can also induce the formation and enrichment of tumor cells, affect their distribution in tumor tissue, and then affect tumor metastasis.
It is difficult to describe the process of cell infiltration and metastasis quantitatively and accurately by traditional methods. Our microfluidic cell patterning technology allows precise manipulation of the cell microenvironment, provides multiple cell culture chambers and cell migration areas, realizes cell co culture without physical damage and real-time monitoring of cell movement, and can quantify the migration process of tumor cells under different conditions (soluble cytokines, cell types and inhibitory drugs, etc.).
At present, the important role of tumor microenvironment in tumorigenesis, tumor progression, invasion and metastasis has been recognized. The development of traditional 2D monolayer tumor cell has inherent limitations, such as poor control of cell density, limited repeatability, low throughput, and lack of replicable control of the spatial distance between cell types (such as cancer cells and stromal cells) in the case of co culture model.
Our cell patterning technology allows accurate control of cell-cell interaction and cell ECM interaction, accurate control of each tumor microenvironment element and Simulation of the in vivo environment, so as to affect the characteristics of proliferative cell polarity, gene expression and signal pathway. The regulation of tumor microenvironment by cell patterning technology can not only help to understand tumorigenesis, tumor progression, invasion and metastasis, but also greatly promote the development of therapeutic agents for tumor microenvironment mediated signals or tumor microenvironment compositions.
Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.