Creative Bioarray can use cell patterning to combine the traditional cell culture matrix with the physiological correlation in vivo, and build an in vitro microenvironment similar to the situation in vivo, so as to improve the correlation and repeatability of the data generated by the in vitro experiment, and reduce the requirements for animal experiments, so as to understand human biology Physiological and genetic mechanisms open up new possibilities.
The complex interaction between tumors and their microenvironment contributes to the occurrence and development of tumor and the development of drug-resistant tumor cell population. The complexity and heterogeneity of tumor and its microenvironment make the research and treatment of cancer challenging. Traditional animal cancer models and in vitro cancer models are limited in their ability to summarize human structure and function, which hinders the determination of appropriate drug targets and treatment strategies.
The development and application of 3D cancer model based on our cell patterning can overcome some inherent limitations of traditional 2D model, provide enhanced quantitative information about complex cell-cell and cell ECM interactions, closely simulate in vivo conditions by combining stromal cells and various ECM conditions, and reproduce the structure and function of solid tumors in vivo. The in vitro cancer model established by our cell patterning can be used as a reliable tool for anticancer drug testing, improve the predictability of new drug compounds in the human body, and save you a lot of time, money and energy.
Central nervous diseases are not only the dysfunction or destruction of neurons and glial cells, but also affected by the interaction between cell microenvironment and various cell types (neurons, astrocytes, endothelial cells, pericytes and skeletal muscle cells). In past studies, animal models were usually used to simulate brain structures and related diseases. However, this method is expensive, inefficient, complex and time-consuming, which seriously limits the development process of drugs for neurological diseases.
The central nervous disease models established by our microfluidic cell patterning generally include microchannels, which are usually used to guide neurite growth, provide controllable mediators and biochemical stimuli, and micro chambers are usually used for long-term cell culture. Our microfluidic cell patterning technology can simulate a variety of central nervous diseases (including Alzheimer's disease, Parkinson's disease, multiple sclerosis, migraine, diffuse axonal injury and epilepsy), better reveal the molecular mechanism of neurodegenerative diseases and provide disease solutions.
Cardiovascular disease is a kind of physiological disease involving the circulatory system, including coronary artery disease, angina pectoris, myocardial infarction, cardiomyopathy and arrhythmia. At present, drug therapy is the main treatment of cardiovascular diseases. Therefore, accurate evaluation of drug efficacy and screening of new drugs are of great significance for more efficient clinical treatment.
Based on microfluidic cell patterning, we can establish pathological and hemodynamic models of cardiovascular diseases, such as atherosclerosis, myocardial infarction, cardiomyopathy, coronary artery disease, thrombosis and so on. These models can accurately adjust the fluid flow conditions in microchannels in vitro, such as flow velocity, shear stress and pulsatile flow, and well simulate the physiological and pathogenic environment of cardiovascular tissues and organs. The model established by our cell patterning technology can provide great possibilities for the diagnosis and treatment of heart diseases in clinical trials, and has great potential for studying the therapeutic mechanism of drugs and screening high-throughput compounds to better discover new drugs.
Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.