Creative Bioarray provides you with cell patterning for in vitro models based on Cell Patterning. We aim to simulate the complex microenvironment and micro ultrastructure in vivo through cell patterning technology, establish a functional in vitro model, and assist you in more effective and faster biological research and preclinical drug development.
The basic relationship between tissue structure, pattern and function, and how these are destroyed during disease, has puzzled biologists for decades. Cell patterning has become a powerful tool to explore and analyze the relationship between cell and tissue structure and the resulting function. Cell patterning technology allows us to locate cells in the basal region in vitro, so as to control the cell shape, location or heterogeneous tissue structure, establish an in vitro model that can better represent the in vivo environment than simple 2D monolayer cells, provide better accuracy in drug discovery and predict the activity of biomolecules more accurately.
Fig.1 In vitro liver model based on cell patterning can be used for drug response. (Lee J.H, et al.,2019)
Our in vitro liver models established by cell patterning technology show continuous liver cell function and good correlation with clearance in vivo, and can maintain liver-specific function. It is of great significance for you to understand liver metabolism, initial liver injury mechanism and study drug hepatotoxicity.
The in vitro heart models established by us through cell patterning technology can summarize some physiological functions of the heart, and customize the exclusive shape according to your application (screening, maturation, regeneration and medicine), providing a powerful tool for you to study the basic mechanism of the heart, cardiac drug screening and regenerative medicine.
The 3D cancer models established by us through cell patterning technology are composed of tumor cells and other cells, which can better simulate the heterogeneous tumor microenvironment and the formation of natural connective tissue in vivo, and provide a powerful tool for you to understand tumorigenesis, tumor progression, invasion and metastasis and develop tumor therapeutic agents.
The in vitro kidney models established by us through cell patterning technology can simulate the physiological environment, summarize the filtration, absorption and excretion of drugs by the kidney, and realize the natural kidney like behavior, which can not only predict the improvement of organogenesis and organoid maturation in the new therapy, but also improve the drug screening and the discovery of nephrotoxicity.
Our skeletal muscle models established by us through cell patterning technology can reproduce the complexity of active muscle tissue and summarize the organization and function of live muscle tissue, so as to increase your understanding of different cell types and their interactions in the process of skeletal muscle formation, and promote your development of new therapies for pathological muscle.
Our vascularized tissue models established through cell patterning technology can create vascular network patterns with the required geometry or size range, which can be used together with other tissue components to create the vascular system, providing you with powerful tools in drug toxicology, drug screening and potential disease modeling.
Our cell patterning technology can generate accurate spatial patterns and create different levels of cartilage tissue by controlling different biomaterial properties and cell types in each print layer, so as to promote the research and development of your cartilage regeneration and help you open up challenging new treatments for joint defects and potential osteoarthritis.
Through cell patterning technology, we can accurately print skin and skin substitutes with high biocompatibility and low immunogenicity according to your needs, and provide you with reliable skin models for pathophysiological research, drug screening or in vitro treatment effect evaluation.
The neural tissue models established by us through cell patterning can better simulate the formation, function and repair of the nervous system, so as to promote your pathological research in the nervous system and diseases, and accelerate the development of potential therapeutic approaches for neurodevelopmental mental disorders and neurodegenerative diseases.
Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.