Creative Bioarray provides you with cell migration guided by cell patterning service to guide cells to migrate continuously along preset paths and directions, so as to facilitate your cell migration research and analysis. At the same time, our professional platform also supports the integrated service of cell patterning customization and migration analysis, which can greatly save your time in research.
Directed cell migration is essential for many important biological processes, including angiogenesis, tumor metastasis, wound healing, embryonic morphogenesis and nerve regeneration. Most of the previous studies on the control of cell movement direction focused on the role of movement factor gradient. Recently, many studies have focused on the development of cell patterning. On the patterned substrate, cells usually show a wide front and narrow rear polarization shape, and can migrate directionally in a short distance. However, this transient geometry cannot be sustained, and cells show random walk behavior on non-patterned surfaces. Specific patterning can induce and guide cells to migrate in the desired direction by providing physical and topographic clues. In addition, cell patterning technology can effectively and consistently provide guidance clues, help us deeply understand the regulatory mechanism of coordinated collective migration, improve our understanding of normal and defective wound healing, and may guide the rational design of tissue repair therapy, biomaterials or scaffolds.
Fig1. Cartoon illustration of typical mammalian cell migration on the plane. (Jiang, X., et al., 2005)
Cell collective migration is a basic biological process, in which cell populations migrate together in a coordinated manner, which is very important for tissue development, morphogenesis and reorganization. For example, wound healing requires effective collective migration of the epithelial layer to repair defects in tissue and restore protective barrier function. The patterned cell shape plays an important role in the distance, speed and direction of cell migration. Creative Bioarray's cell patterning technology allows you to systematically study the impact of geometric constraints on cell collective migration, and provides physical guidance for you to study cell rapid movement and directional migration. It helps you to deeply understand the regulatory mechanism of coordinating collective migration, and improve your understanding of normal and defective wound healing. Biopatterning can be used as a promising biological function platform and cell guiding matrix, and can be applied to tissue repair therapy, rational design of biomaterials or scaffolds.
Under the influence of stimulation (chemical or mechanical), cells can polarize and move directionally (towards or away from stimulation). However, it is not clear whether the morphological polarity of the cell itself can determine the direction of movement. Creative Bioarray's cell patterning technology can provide asymmetric pattern substrate to define the polarity of adherent cells, and provide the opportunity to study single polarized cells, avoiding cell-cell contact, which is convenient for you to investigate the relationship between the initial direction of cell movement and the polarity of its original shape. In addition, we can manipulate the cell culture conditions through cell patterning technology to simulate the cell microenvironment, so as to provide a dynamic, complex and micron scale environment. We can also well observe the cell migration induced by different protein substrate shapes.
We use lithography to customize the most appropriate exclusive pattern according to your cell type to guide the continuous migration of cells along the preset path and direction, so as to facilitate your cell migration research and analysis. At the same time, our professional platform also supports the integrated service of cell patterning customization and migration analysis, which can greatly save your time.
Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.